| 8/28 | Mark Twain | @ | South Callaway | Cancellled | |||
| 9/4 | Mark Twain | 34 | vs | Clopton/Elsberry | 51 | ||
| 9/12 | Mark Twain | 8 | vs | Van-Far/Community R-VI | 6 | ||
| 9/18 | Mark Twain | 14 | @ | Missouri Military Academy | 23 | ||
| 9/25 | Mark Twain | 0 | @ | Bowling Green | 35 | ||
| 10/2 | Mark Twain | 36 | vs | Wright City | 16 | ||
| 10/9 | Mark Twain | 14 | @ | Montgomery County | 48 | ||
| 10/16 | Mark Twain | 12 | @ | North Callaway | 47 | ||
| 10/23 | Mark Twain | 26 | vs | Louisiana | 6 | ||
| Districts – Class 1 District 2 | |||||||
| 10/30 | (2) Mark Twain | 18 | vs | (7) South Shelby | 14 | Opening Round | |
| 11/6 | (2) Mark Twain | 36 | vs | (6) Louisiana | 24 | Semi-Final | |
| 11/13 | (2) Mark Twain | vs | (1) South Callaway | Championship | |||