Class 1 Region 2 First Team
| Name | School | Position | ||||
| Olivia Meisenheimer | Jamestown | Pitcher | ||||
| Olivia Cross | Cairo | Pitcher | ||||
| Brooklyn Morris | Glasgow | Pitcher | ||||
| Kyleigh Haston | Brunswick/Keytesville/Northwest | Pitcher | ||||
| Kylee Dodge | Cairo | Catcher | ||||
| Layne Sanders | Glasgow | Catcher | ||||
| Jolene Sorrells | Jamestown | Catcher | ||||
| Ayla King | Salisbury | Infield | ||||
| Madison Haldiman | Jamestown | Infield | ||||
| Chloe Brumley | Cairo | Infield | ||||
| Tori Ricketts | Salisbury | Infield | ||||
| Kaylyn Campbell | Glasgow | Infield | ||||
| Lily Chitwood | New Franklin | Infield | ||||
| Sarah Weatherford | Silex | Outfield | ||||
| Hailey Hearting | Montrose/Appleton City/Ballard | Outfield | ||||
| Halle Fuemmeler | Glasgow | Outfield | ||||
| Addison Schiltz | Salisbury | Outfield | ||||
| Paige Painter | Community R-6 | Utility | ||||
| Brooklyn Glasgow | Community R-6 | At-Large |
Class 1 Region 2 Second Team
| Name | School | ||
| Jocelyn Curtis | Community R-6 | ||
| Grace Gebhardt | Salisbury | ||
| Julia Sloan | Salisbury | ||
| Kaylee Mott | Montrose/Appleton City/Ballard | ||
| Jaden Mauzey | Brunswick/Keytesville/Northwest | ||
| Austyn Van Horn | Silex | ||
| Sydney Derendinger | Jamestown | ||
| Avery Wraight | Montrose/Appleton City/Ballard | ||
| Addison Bailey | Cairo |