EAGLE 102 SPORTS — The Missouri High School Fastpitch Coaches Association released the 2021 All-Region teams. Below are the players named to Class 2 Region 3 All-Region Team.
| First Team | |||
| Name | School | Position | Grade |
| Claire Tipton | Putnam County | Pitcher | Senior |
| Cassi Rodgers | Marceline | Pitcher | Junior |
| Jazlin Gottman | Palmyra | Pitcher | Senior |
| Gracey Jordan | Marceline | Catcher | Senior |
| Allie Hayden | Clark County | Catcher | Senior |
| Addison Huber | Marceline | Infield | Junior |
| Emma Harshberger | Highland | Infield | Sophomore |
| Mackenzie Moss | Monroe City | Infield | Senior |
| Kaliska Madison | South Harrison | Infield | Junior |
| Olivia Miller | Clark County | Infield | Junior |
| Carly Youngblood | Monroe City | Outfield | Senior |
| Sarah Kussman | Marceline | Outfield | Senior |
| Ally Fox | Clark County | Outfield | Junior |
| Cady Pauley | Milan | At Large | Senior |
| Audri Youngblood | Monroe City | At Large | Freshman |
| Second Team | |||
| Name | School | Position | Grade |
| Hannah Carter | South Harrison | Pitcher | Sophomore |
| Kailynn Fuemmeler | Monroe City | Pitcher | Junior |
| Payton Miller | Highland | Pitcher | Junior |
| Jillian Hurt | South Harrison | Catcher | Senior |
| Sam Daniels | Putnam County | Catcher | Senior |
| Autumn Arndt | Mark Twain | Catcher | Senior |
| Abbey Redd | Palmyra | Infield | Junior |
| Chandler Lynch | Trenton | Infield | Senior |
| Ireland Bloss | Marceline | Infield | Sophomore |
| Madi Allen | Penney | Infield | Sophomore |
| Alli Jenkins | Louisiana | Infield | Sophomore |
| Mikayla Dreyer | Highland | Outfield | Junior |
| Bella McBride | Palmyra | Outfield | Sophomore |
| Shay Westerhoff | Trenton | Outfield | Senior |
| Ella Lowe | Marceline | At Large | Junior |