| Date | School | Opponent | |||
| 1-Oct | Bowling Green | 56 | vs | North Callaway | 6 |
| Louisiana | 65 | vs | Missouri Military Academy | 0 | |
| Mark Twain | 52 | @ | Wright City | 7 | |
| Pittsfield | 29 | vs | New Berlin | 0 | |
| Pleasant Hill/Western | 8 | vs | Calhoun | 22 | |
| Van-Far | 0 | vs | South Callaway | 35 | |
| Winfield | 70 | vs | St Charles | 28 | |
| 8-Oct | Louisiana | 0 | vs | Bowling Green | 56 |
| Mark Twain | 38 | vs | Montgomery County | 8 | |
| Pittsfield | 6 | vs | Athens | 52 | |
| Pleasant Hill/Western | 0 | @ | Greenfield | 50 | |
| Van-Far | 32 | @ | Uniontown | 46 | |
| Winfield | 43 | @ | Warrenton | 28 | |
| 15-Oct | Bowling Green | 55 | @ | South Callaway | 14 |
| Louisiana | 26 | @ | Wright City | 15 | |
| Mark Twain | 22 | vs | North Callaway | 8 | |
| Pleasant Hill/Western | 7 | @ | Triopia | 41 | |
| Van-Far | 8 | @ | Montgomery County | 38 | |
| Winfield | 0 | vs | Duchesne | 62 | |
| 16-Oct | Pittsfield | 14 | @ | Porta | 6 |
| 22-Oct | Bowling Green | 24 | vs | Cardinal Ritter | 20 |
| Louisiana | 13 | vs | Mark Twain | 40 | |
| Pittsfield | 16 | vs | Williamsville | 44 | |
| Van-Far | 26 | @ | Scotland County | 58 | |
| Winfield | 0 | vs | Lift For Life | 38 | |
| 23-Oct | Pleasant Hill/Western | 7 | vs | Beardstown | 43 |
| 29-Oct | Class 2 District 6 | ||||
| (2) Bowling Green | 70 | vs | (7) Missouri Military Academy | 0 | |
| Class 1 District 2 | |||||
| (5) Louisiana | 36 | @ | (4) Brentwood | 38 | |
| (2) Mark Twain | 13* | vs | (7) Principia | 0 | |
| (8) Van-Far | 16 | @ | (1) Monroe City | 70 | |
| Class 3 District 3 | |||||
| (5) Winfield | 7 | @ | (4) Orchard Farm | 21 | |
| *Forfeit default score | |||||