| Date | School | vs/@ | Opponent | ||
| Thu, Sep 01, 22 | Bowling Green | 6 | vs | Louisiana | 0 |
| Thu, Sep 01, 22 | Clopton | 10 | vs | Wellsville-Middletown | 0 |
| Thu, Sep 01, 22 | Elsberry | 10 | @ | Wright City | 6 |
| Thu, Sep 01, 22 | Louisiana | 0 | @ | Bowling Green | 6 |
| Thu, Sep 01, 22 | Mark Twain | 6 | vs | Palmyra | 18 |
| Thu, Sep 01, 22 | Silex | 11 | vs | Montgomery County | 3 |
| Thu, Sep 01, 22 | Van-Far | 4 | vs | North Callaway | 15 |
| Fri, Sep 02, 22 | Silex | 8 | vs | Winfield | 0 |
| Tue, Sep 06, 22 | Bowling Green | 0 | @ | Elsberry | 1 |
| Tue, Sep 06, 22 | Elsberry | 1 | vs | Bowling Green | 0 |
| Tue, Sep 06, 22 | Louisiana | 3 | vs | Silex | 15 |
| Tue, Sep 06, 22 | Mark Twain | 11 | @ | Montgomery County | 1 |
| Tue, Sep 06, 22 | Silex | 15 | @ | Louisiana | 3 |
| Tue, Sep 06, 22 | Van-Far | 12 | @ | Madison | 0 |
| Wed, Sep 07, 22 | Bowling Green | 1 | vs | Canton | 12 |
| Wed, Sep 07, 22 | Elsberry | 6 | vs | South Shelby | 1 |
| Wed, Sep 07, 22 | Van-Far | 3 | vs | Paris | 8 |
| Thu, Sep 08, 22 | Bowling Green | 9 | vs | Mark Twain | 1 |
| Thu, Sep 08, 22 | Clopton | 0 | vs | Elsberry | 1 |
| Thu, Sep 08, 22 | Elsberry | 1 | @ | Clopton | 0 |
| Thu, Sep 08, 22 | Louisiana | 9 | vs | Van-Far | 3 |
| Thu, Sep 08, 22 | Mark Twain | 1 | @ | Bowling Green | 9 |
| Thu, Sep 08, 22 | Silex | 13 | @ | Community | 3 |
| Thu, Sep 08, 22 | Van-Far | 3 | @ | Louisiana | 9 |
| Sat, Sep 10, 22 | Bowling Green | vs | Battle | Cancelled | |
| Elsberry Invitational Tournament – Opening Round | |||||
| Sat, Sep 10, 22 | (1) Elsberry | 6 | vs | (8) Troy JV | 4 |
| (2) Union | 0 | vs | (7) Louisiana | 9 | |
| (3) Silex | 4 | vs | (6) Montgomery County | 7 | |
| (4) North Shelby | 4 | vs | (5) Clopton | 7 | |
| Elsberry Invitational Tournament – Semi-Finals | |||||
| Sat, Sep 10, 22 | (1) Elsberry | 1 | vs | (5) Clopton | 7 |
| (7) Louisiana | 5 | vs | (6) Montgomery County | 4 | |
| (8) Troy JV | 1 | vs | (4) North Shelby | 11 | |
| (2) Union | 6 | vs | (3) Silex | 7 | |
| Elsberry Invitational Tournament – Championships | |||||
| Sat, Sep 10, 22 | (5) Clopton | 9 | vs | (7) Louisiana | 0 |
| (1) Elsberry | 10 | vs | (6) Montgomery County | 0 | |
| (4) North Shelby | 2 | vs | (3) Silex | 7 | |
| Mon, Sep 12, 22 | Bowling Green | 10 | @ | Hannibal | 0 |
| Mon, Sep 12, 22 | Clopton | 1 | @ | North Shelby | 6 |
| Mon, Sep 12, 22 | Louisiana | 0 | @ | Highland | 14 |
| Tue, Sep 13, 22 | Bowling Green | 7 | @ | Montgomery County | 0 |
| Tue, Sep 13, 22 | Clopton | 4 | @ | North Callaway | 3 |
| Tue, Sep 13, 22 | Elsberry | 4 | vs | Van-Far | 1 |
| Tue, Sep 13, 22 | Louisiana | 14 | vs | Wright City | 13 |
| Tue, Sep 13, 22 | Mark Twain | 8 | vs | Silex | 11 |
| Tue, Sep 13, 22 | Silex | 11 | @ | Mark Twain | 8 |
| Tue, Sep 13, 22 | Van-Far | 4 | @ | Elsberry | 1 |
| Wed, Sep 14, 22 | Mark Twain | 4 | vs | South Shelby | 13 |
| Thu, Sep 15, 22 | Bowling Green | 1 | @ | Palmyra | 0 |
| Thu, Sep 15, 22 | Clopton | 4 | vs | Montgomery County | 1 |
| Thu, Sep 15, 22 | Elsberry | 8 | @ | North Callaway | 0 |
| Thu, Sep 15, 22 | Louisiana | 12 | @ | Wellsville-Middletown | 1 |
| Thu, Sep 15, 22 | Mark Twain | 13 | @ | Van-Far | 2 |
| Thu, Sep 15, 22 | Silex | 8 | @ | Canton | 10 |
| Thu, Sep 15, 22 | Van-Far | 2 | vs | Mark Twain | 13 |
| Fri, Sep 16, 22 | Silex | 7 | vs | Liberty (Wentzville) | 13 |
| Sat, Sep 17, 22 | Bowling Green | 3 | vs | Liberty (Wentzville) | 2 |
| North Shelby Tournament | |||||
| Sat, Sep 17, 22 | Mark Twain | 3 | vs | North Shelby | 13 |
| Mark Twain | 11 | vs | Marion County | 6 | |
| Mark Twain | 7 | vs | Bevier | 5 | |
| Van-Far | 17 | vs | Marion County | 2 | |
| Mon, Sep 19, 22 | Elsberry | 6 | @ | Palmyra | 7 |
| Mon, Sep 19, 22 | Louisiana | 1 | @ | North Shelby | 12 |
| Mon, Sep 19, 22 | Mark Twain | 13 | @ | Madison | 11 |
| Mon, Sep 19, 22 | Silex | 11 | @ | Wright City | 5 |
| Tue, Sep 20, 22 | Bowling Green | 4 | @ | Silex | 3 |
| Tue, Sep 20, 22 | Clopton | 11 | @ | Louisiana | 0 |
| Tue, Sep 20, 22 | Elsberry | 15 | vs | Wellsville-Middletown | 0 |
| Tue, Sep 20, 22 | Louisiana | 0 | vs | Clopton | 11 |
| Tue, Sep 20, 22 | Mark Twain | 12 | vs | Wright City | 13 |
| Tue, Sep 20, 22 | Silex | 3 | vs | Bowling Green | 4 |
| Tue, Sep 20, 22 | Van-Far | 0 | @ | Montgomery County | 3 |
| Wed, Sep 21, 22 | Bowling Green | 1 | @ | Capital City | 0 |
| Thu, Sep 22, 22 | Bowling Green | 10 | @ | Van-Far | 0 |
| Thu, Sep 22, 22 | Clopton | 7 | vs | Silex | 2 |
| Thu, Sep 22, 22 | Elsberry | 1 | vs | Louisiana | 0 |
| Thu, Sep 22, 22 | Louisiana | 0 | @ | Elsberry | 1 |
| Thu, Sep 22, 22 | Mark Twain | 17 | @ | Wellsville-Middletown | 0 |
| Thu, Sep 22, 22 | Silex | 2 | @ | Clopton | 7 |
| Thu, Sep 22, 22 | Van-Far | 0 | vs | Bowling Green | 10 |
| Fri, Sep 23, 22 | Clopton | @ | Marion County | Cancelled | |
| Sat, Sep 24, 22 | Clopton | @ | Bulldog Invitational | Cancelled | |
| Sat, Sep 24, 22 | Elsberry | @ | Bulldog Invitational | Cancelled | |
| Sat, Sep 24, 22 | Louisiana | vs | Bulldog Invitational | Cancelled | |
| Sat, Sep 24, 22 | Mark Twain | @ | Bulldog Invitational | Cancelled | |
| Sat, Sep 24, 22 | Silex | @ | Bulldog Invitational | Cancelled | |
| Sat, Sep 24, 22 | Van-Far | @ | Bulldog Invitational | Cancelled | |
| Mon, Sep 26, 22 | Mark Twain | 1 | vs | Community | 19 |
| Mon, Sep 26, 22 | Van-Far | 20 | @ | Wellsville-Middletown | 3 |
| Tue, Sep 27, 22 | Bowling Green | 9 | vs | Wright City | 2 |
| Tue, Sep 27, 22 | Clopton | 24 | @ | Mark Twain | 0 |
| Tue, Sep 27, 22 | Louisiana | 14 | vs | North Callaway | 4 |
| Tue, Sep 27, 22 | Mark Twain | 0 | vs | Clopton | 24 |
| Tue, Sep 27, 22 | Silex | 16 | @ | Van-Far | 0 |
| Tue, Sep 27, 22 | Van-Far | 0 | vs | Silex | 16 |
| Wed, Sep 28, 22 | Elsberry | 2 | vs | Highland | 0 |
| Wed, Sep 28, 22 | Louisiana | 0 | @ | Monroe City | 10 |
| Thu, Sep 29, 22 | Bowling Green | 1 | @ | Wellsville-Middletown | 0 FFT |
| Thu, Sep 29, 22 | Clopton | 3 | vs | Wright City | 2 |
| Thu, Sep 29, 22 | Elsberry | 14 | vs | Mark Twain | 1 |
| Thu, Sep 29, 22 | Louisiana | 7 | vs | Montgomery County | 6 |
| Thu, Sep 29, 22 | Mark Twain | 1 | @ | Elsberry | 14 |
| Thu, Sep 29, 22 | Silex | 6 | @ | North Callaway | 2 |
| Thu, Sep 29, 22 | Van-Far | 3 | @ | Community | 7 |
| Hickman Tournament – Pool Play | |||||
| Fri, Sep 30, 22 | Bowling Green | 0 | vs | Capital City | 6 |
| Bowling Green | 15 | vs | Hickman | 0 | |
| Fri, Sep 30, 22 | Elsberry | 11 | vs | Ft. Zumwalt East | 4 |