| Date | School | vs/@ | Opponent | ||
| Fri, Sep 02, 22 | Bowling Green | 71 | vs | Palmyra | 12 |
| Fri, Sep 02, 22 | Louisiana | 20 | @ | Crystal City | 40 |
| Fri, Sep 02, 22 | Mark Twain | 46 | vs | Winfield/Elsberry | 9 |
| Fri, Sep 02, 22 | Pittsfield | 12 | @ | Olympia | 51 |
| Fri, Sep 02, 22 | Pleasant Hill | 0 | @ | Camp Point Central | 46 |
| Fri, Sep 02, 22 | Van-Far | 6 | @ | Russellville | 19 |
| Fri, Sep 02, 22 | Winfield/Elsberry | 9 | @ | Mark Twain | 46 |
| Fri, Sep 09, 22 | Louisiana | 31 | vs | Father Tolton | 34 |
| Fri, Sep 09, 22 | Mark Twain | 6 | @ | Wright City | 21 |
| Fri, Sep 09, 22 | Pittsfield | 0 | vs | Williamsville | 42 |
| Fri, Sep 09, 22 | Pleasant Hill | 0 | @ | Carrollton | 48 |
| Fri, Sep 09, 22 | Van-Far | 14 | vs | Montgomery County | 12 |
| Fri, Sep 09, 22 | Winfield/Elsberry | 21 | vs | Moberly | 39 |
| Sat, Sep 10, 22 | Bowling Green | 72 | St. Mary’s Academy | 8 | |
| Fri, Sep 16, 22 | Bowling Green | 64 | @ | Van-Far | 6 |
| Fri, Sep 16, 22 | Louisiana | 12 | @ | North Callaway | 29 |
| Fri, Sep 16, 22 | Mark Twain | 50 | @ | Montgomery County | 18 |
| Fri, Sep 16, 22 | Pittsfield | 7 | @ | New Berlin | 39 |
| Fri, Sep 16, 22 | Pleasant Hill | 6 | vs | Winchester | 46 |
| Fri, Sep 16, 22 | Van-Far | 6 | vs | Bowling Green | 64 |
| Fri, Sep 16, 22 | Winfield/Elsberry | 21 | @ | St. Charles West | 43 |
| Fri, Sep 23, 22 | Bowling Green | 74 | vs | Montgomery County | 0 |
| Fri, Sep 23, 22 | Louisiana | 32 | vs | South Callaway | 28 |
| Fri, Sep 23, 22 | Mark Twain | 22 | vs | North Callaway | 34 |
| Fri, Sep 23, 22 | Pittsfield | 12 | vs | Maroa-Forsyth | 42 |
| Fri, Sep 23, 22 | Pleasant Hill | 50 | vs | North Greene | 26 |
| Fri, Sep 23, 22 | Van-Far | 28 | vs | Wright City | 41 |
| Fri, Sep 23, 22 | Winfield/Elsberry | 21 | vs | Orchard Farm | 14 |
| Thu, Sep 29, 22 | Pleasant Hill | 0 | @ | Calhoun | 55 |
| Fri, Sep 30, 22 | Bowling Green | 69 | vs | South Callaway | 14 |
| Fri, Sep 30, 22 | Louisiana | 14 | @ | Mark Twain | 38 |
| Fri, Sep 30, 22 | Mark Twain | 38 | vs | Louisiana | 14 |
| Fri, Sep 30, 22 | Pittsfield | 12 | @ | Pleasant Plains | 43 |
| Fri, Sep 30, 22 | Van-Far | 16 | @ | North Callaway | 36 |
| Fri, Sep 30, 22 | Winfield/Elsberry | 28 | @ | St. Charles High | 30 |