| Date | School | vs/@ | Opponent | ||
| Thu, Oct 06, 22 | Pleasant Hill | 0 | vs | Greenfield | 42 |
| Fri, Oct 07, 22 | Bowling Green | 76 | @ | Mark Twain | 6 |
| Fri, Oct 07, 22 | Louisiana | 12 | vs | Montgomery County | 22 |
| Fri, Oct 07, 22 | Mark Twain | 2 | vs | Bowling Green | 76 |
| Fri, Oct 07, 22 | Pittsfield | 0 | vs | Auburn | 34 |
| Fri, Oct 07, 22 | Van-Far | 14 | @ | Crystal City | 37 |
| Fri, Oct 07, 22 | Winfield/Elsberry | 7 | vs | Warrenton | 28 |
| Fri, Oct 14, 22 | Bowling Green | 83 | vs | Wright City | 7 |
| Fri, Oct 14, 22 | Louisiana | 36 | @ | Van-Far | 6 |
| Fri, Oct 14, 22 | Mark Twain | 8 | @ | South Callaway | 46 |
| Fri, Oct 14, 22 | Pleasant Hill | 30 | vs | Triopia | 34 |
| Fri, Oct 14, 22 | Van-Far | 6 | vs | Louisiana | 36 |
| Fri, Oct 14, 22 | Winfield/Elsberry | 32 | @ | Cuba | 12 |
| Sat, Oct 15, 22 | Pittsfield | 24 | @ | Porta | 14 |
| Fri, Oct 21, 22 | Bowling Green | 61 | @ | North Callaway | 12 |
| Fri, Oct 21, 22 | Louisiana | 50 | vs | Wright City | 47 |
| Fri, Oct 21, 22 | Mark Twain | 64 | vs | Van-Far | 8 |
| Fri, Oct 21, 22 | Pittsfield | 34 | vs | Riverton | 12 |
| Fri, Oct 21, 22 | Pleasant Hill | 8 | @ | Beardstown | 40 |
| Fri, Oct 21, 22 | Van-Far | 8 | vs | Mark Twain | 64 |
| Fri, Oct 21, 22 | Winfield/Elsberry | 20 | @ | Fulton | 28 |
| Fri, Oct 28, 22 | (6)Louisiana | 28 | vs | (3)Crystal City | 24 |
| Fri, Oct 28, 22 | (3)Mark Twain | 16 | vs | (6)Highland | 32 |
| Fri, Oct 28, 22 | Winfield/Elsberry | 0 | vs | Kirksville | 59 |