| Date | School | vs/@ | Opponent | ||
| Thu, Aug 25, 22 | Pittsfield | 40 | vs | Athens | 0 |
| Fri, Aug 26, 22 | Bowling Green | 68 | vs | Louisiana | 8 |
| Fri, Aug 26, 22 | Louisiana | 8 | @ | Bowling Green | 68 |
| Fri, Aug 26, 22 | Mark Twain | 8 | @ | Monroe City | 48 |
| Fri, Aug 26, 22 | Van-Far | 22 | @ | South Callaway | 44 |
| Fri, Aug 26, 22 | Winfield/Elsberry | 19 | vs | Wright City | 27 |
| Sat, Aug 27, 22 | Pleasant Hill | 0 | vs | Routt Catholic | 54 |