EAGLE 102 SPORTS — The Missouri High School Fastpitch Coaches Association released the 2021 All-Region teams. Below are the players named to Class 1 Region 2 All-Region Team.
| First Team | |||
| Name | School | Position | Grade |
| Riley Hammond | St. Elizabeth | Pitcher | Freshman |
| Taylor Howard | Silex | Pitcher | Senior |
| Brynn Belstle | New Franklin | Pitcher | Freshman |
| Shana Yates | Clopton | Pitcher | Junior |
| Avery Brumley | Cairo | Catcher | Freshman |
| Ella Lucas | St. Elizabeth | Catcher | Sophomore |
| Mackenzie Wilson | New Haven | Catcher | Senior |
| Tasia Green | St. Elizabeth | Infield | Senior |
| Abagail Mooney | Silex | Infield | Sophomore |
| Tori Kemna | St. Elizabeth | Infield | Junior |
| Abby Maupin | New Franklin | Infield | Senior |
| Renna Black | Westran | Infield | Senior |
| Devyn Keller | Van Far | Infield | Senior |
| Iszy Zenker | Cairo | Infield | Junior |
| Gwen Gilbert | Silex | Outfield | Senior |
| Abi Ogle | Cairo | Outfield | Junior |
| Kadence George | Vienna | Outfield | Senior |
| Kenzie Dawson | Westran | Outfield | Senior |
| Emily Wilde | St. Elizabeth | At-Large | Senior |
| Second Team | |||
| Name | School | Position | Grade |
| Morgan Taylor | Cairo | Pitcher | Senior |
| Abrea Simmons | Vienna | Pitcher | Junior |
| Marci Lammers | Pilot Grove | Pitcher | Junior |
| Maddy Harvey | Westran | Pitcher | Senior |
| Terra Huffman | Vienna | Catcher | Junior |
| Grace Peterson | Pilot Grove | Catcher | Junior |
| Sara Grateke | Silex | Catcher | Junior |
| Kaitlyn Maggard | Pilot Grove | Infield | Junior |
| Trinity Paulson | Jamestown | Infield | Senior |
| Gracie Brumley | Cairo | Infield | Junior |
| Cheyenne Minks | Tuscombia | Infield | Senior |
| Rita Thoroughman | Silex | Infield | Junior |
| Riley Rosentreter | Vienna | Outfield | Junior |
| Lauren Otto | St. Elizabeth | Outfield | Senior |
| Madilyn Ingram | Van-Far | Outfield | Senior |
| Jillian Johnanning | Glasgow | Outfield | Senior |
| Tori Mudd | Silex | At-Large | Junior |