EAGLE 102 SPORTS — The Missouri High School Fastpitch Coaches Association released the 2021 All-Region teams. Below are the players named to Class 2 Region 2 All-Region Team.
| First Team | |||
| Name | School | Position | Grade |
| Brooklyn Fischer | Montgomery County | Pitcher | Senior |
| Jordyn Ball | Fayette | Pitcher | Senior |
| Jaden Howard | Salisbury | Pitcher | Junior |
| Addyson Steele | Elsberry | Pitcher | Junior |
| Asya Nichols | New Bloomfield | Pitcher | Senior |
| Cayden Stapleton | Salisbury | Catcher | Senior |
| Brooklyn Talbot | New Bloomfield | Catcher | Senior |
| Makenzie Gladney | Elsberry | Catcher | Junior |
| Khloe Wyatt | Salisbury | Infield | Senior |
| Avery Nichols | New Bloomfield | Infield | Junior |
| Mya Pflasterer | Elsberry | Infield | Freshman |
| Megan Lewis | Fayette | Infield | Junior |
| Macie Abbott | New Bloomfield | Infield | Freshman |
| Preslee Sunderland | Fayette | Infield | Junior |
| Hannah Quint | Fayette | Outfield | Junior |
| Brooklynn Smith | New Bloomfield | Outfield | Junior |
| Kelsey Pflasterer | Elsberry | Outfield | Senior |
| Katie Starbuck | Harrisburg | Utility | Senior |
| Second Team | |||
| Name | School | Grade | |
| Sam Queathem | Montgomery County | Senior | |
| Maddy Queathem | Montgomery County | Sophomore | |
| Emma Fischer | Harrisburg | Sophomore | |
| Cami Menke | Jefferson | Senior | |
| Payton Robinson | Elsberry | Senior | |
| Breanne Haines | Salisbury | Senior | |
| Anna Talbot | Elsberry | Freshman | |
| Katy Talbot | Elsberry | Freshman |