| Date | School | Opponent | |||
| 3-Sep | Bowling Green | 45 | @ | Palmyra | 0 |
| Louisiana | 13 | @ | Montgomery County | 41 | |
| Pittsfield | 31 | @ | Riverton | 21 | |
| Pleasant Hill/Western | 0 | vs | Camp Point Central | 34 | |
| Winfield | 15 | vs | Monroe City | 46 | |
| 4-Sep | Mark Twain | 36 | @ | Lexington | 6 |
| Van-Far | 32 | vs | Wright City | 48 | |
| 10-Sep | Bowling Green | 51 | @ | Montgomery County | 7 |
| Louisiana | 12 | @ | South Callaway | 34 | |
| Pittsfield | 31 | vs | Auburn | 24 | |
| Pleasant Hill/Western | 14 | vs | Carrollton | 55 | |
| Van-Far | 14 | vs | Mark Twain | 54 | |
| Winfield | 63 | @ | Wright City | 19 | |
| 17-Sep | Bowling Green | vs | Wright City | ||
| Louisiana | 48 | Crystal City | 28 | ||
| Mark Twain | 55 | vs | Missouri Military Academy | 6 | |
| Pittsfield | 0 | vs | Maroa-Forsyth | 70 | |
| Pleasant Hill/Western | @ | Winchester | |||
| Van-Far | 0 | @ | North Callaway | 56 | |
| Winfield | 50 | vs | St. Charles West | 0 | |
| 24-Sep | Mark Twain | 28 | vs | Bowling Green | 14 |
| Pittsfield | 2 | @ | North Mac | 48 | |
| Pleasant Hill/Western | 32 | @ | North Greene | 16 | |
| Van-Far | 6 | vs | Louisiana | 41 | |
| Winfield | 20 | @ | Orchard Farm | 41 |