| 3/19/21 | Bowling Green | vs | Hallsville | Postponed | ||
| Elsberry | vs | Mark Twain | Postponed | |||
| Silex | vs | Monroe City | Postponed | |||
| 3/22/21 | Elsberry | 5 | vs | Lutheran North | 3 | |
| Silex | 3 | vs | Louisiana | 9 | ||
| Van-Far | 1 | @ | Calvary Lutheran | 11 | ||
| 3/23/21 | Bowling Green | vs | Centralia | Postponed | ||
| Elsberry | @ | Palmyra | Postponed | |||
| 3/24/21 | Elsberry | 0 | @ | Palmyra | 3 | |
| 3/25/21 | Clopton | vs | Silex | Postponed | ||
| Elsberry | @ | Winfield | Postponed | |||
| Louisiana | vs | Bowling Green | Postponed | |||
| Mark Twain | vs | Missouri Military Academy | Postponed | |||
| 3/26/21 | Clopton | vs | Wellsville-Middletown | Postponed | ||
| Elsberry | 2 | vs | Winfield | 8 | ||
| Louisiana | 1 | vs | Bowling Green | 12 | ||
| 3/27/21 | Bowling Green | 7 | @ | Centralia | 11 | |
| Elsberry | 2 | vs | Orchard Farm | 4 | ||
| Elsberry | 7 | vs | Lutheran North | 3 | ||
| Mark Twain | 0 | @ | Cario | 11 | ||
| Mark Twain | @ | Schuyler County (@ Cario) | V | |||
| 3/29/21 | Louisiana | 5 | @ | Wellsville-Middletown | 9 | |
| Silex | 0 | vs | Montgomery County | 13 | ||
| Van-Far | 0 | vs | Hermann | 18 | ||
| 3/30/21 | Clopton | 4 | vs | Wellsville-Middletown | 7 | |
| Elsberry | 0 | @ | Wright City | 3 | ||
| Mark Twain | 0 | @ | Canton | 15 | ||
| Van-Far | 5 | vs | North Callaway | 16 | ||
| 3/31/21 | Silex | 1 | vs | Hermann | 17 | |
| Updated 03.31.21 |