| 4/1/21 | Clopton | 1 | vs | Louisiana | 11 | |
| Elsberry | 5 | vs | Bowling Green | 3 | ||
| Mark Twain | 1 | @ | Montgomery County | 11 | ||
| Silex | 6 | @ | Community R-VI | 3 | ||
| Van-Far | 4 | @ | Wellsville-Middletown | 14 | ||
| 4/2/21 | Louisiana | 3 | @ | Clark County | 7 | |
| 4/5/21 | Bowling Green | 12 | @ | Palmyra | 14 | |
| Louisiana | 0 | @ | Winfield | 10 | ||
| Mark Twain | 0 | vs | Centralia | 15 | ||
| 4/6/21 | Bowling Green | 5 | vs | North Callaway | 2 | |
| Clopton | 7 | @ | Marion County | 0 | ||
| Mark Twain | 0 | @ | Paris | 10 | ||
| Silex | 7 | vs | Elsberry | 12 | ||
| 4/8/21 | Bowling Green | vs | Mark Twain | Postponed | ||
| Clopton | 0 | vs | Elsberry | 12 | ||
| Louisiana | @ | Canton | Postponed | |||
| Van-Far | vs | Community R-VI | Postponed | |||
| 4/9/21 | Bowling Green | 10 | vs | Mark Twain | 7 | |
| Louisiana | 2 | @ | Canton | 6 | ||
| 4/10/21 | Marion County Triangular | |||||
| Silex | @ | Marion County | Cancelled | |||
| Silex | @ | LaPlata | Cancelled | |||
| 4/12/21 | Bowling Green | 5 | vs | Winfield | 11 | |
| Louisiana | 1 | vs | Elsberry | 2 | ||
| Mark Twain | 0 | vs | Silex | 7 | ||
| Van-Far | 2 | @ | Marion County | 12 | ||
| 4/13/21 | Bowling Green | 5 | @ | Montgomery County | 4 | |
| Clopton | 4 | @ | Community R-VI | 6 | ||
| Elsberry | 12 | vs | Van-Far | 0 | ||
| Elsberry | 11 | vs | Mark Twain | 1 | ||
| Louisiana | 4 | vs | Wright City | 11 | ||
| 4/14/21 | Silex | 1 | @ | Wright City | 11 | |
| 4/15/21 | Clopton | 0 | vs | Montgomery County | 10 | |
| Elsberry | 7 | @ | North Callaway | 2 | ||
| Silex | 1 | @ | Hannibal | 11 | ||
| Van-Far | 9 | vs | Mark Twain | 11 | ||
| 4/16/21 | Bowling Green | 5 | @ | Duschesne | 2 | |
| Louisiana | 6 | vs | Missouri Military Academy | 9 | ||
| 4/19/21 | Bowling Green | 3 | @ | Macon | 13 | |
| Elsberry | 11 | vs | Wellsville-Middletown | 4 | ||
| Louisiana | 13 | vs | Highland | 0 | ||
| Mark Twain | 2 | vs | North Callaway | 21 | ||
| Van-Far | 0 | @ | Wright City | 16 | ||
| 4/20/21 | Louisiana | @ | Community R-VI | Postponed | ||
| Mark Twain | vs | Wright City | Postponed | |||
| Silex | vs | Bowling Green | Postponed | |||
| Van-Far | @ | Montgomery County | Postponed | |||
| 4/21/21 | Louisiana | 6 | @ | Community R-VI | 5 | |
| 4/22/21 | Louisiana | 5 | @ | South Shelby | 3 | |
| Mark Twain | 5 | @ | Wellsville-Middletown | 15 | ||
| Silex | 16 | @ | Crossroads College Prep | 3 | ||
| Van-Far | 0 | vs | Bowling Green | 5 | ||
| 4/23/21 | Mark Twain | 0 | vs | Wright City | 18 | |
| 4/24/21 | Silex | vs | Missouri Military Academy | V/JV | Cancelled | |
| 4/26/21 | Elsberry | 8 | vs | Warrenton | 7 | |
| Mark Twain | 16 | vs | Highland | 15 | ||
| Silex | 17 | vs | Van-Far | 2 | ||
| 4/27/21 | Bowling Green | 2 | vs | Wright City | 6 | |
| Louisiana | 8 | vs | North Callaway | 11 | ||
| 4/29/21 | Bowling Green | @ | Wellsville-Middletown | Postponed | ||
| Louisiana | 6 | vs | Montgomery County | 12 | ||
| Silex | @ | North Callaway | Postponed | |||
| 4/30/21 | Bowling Green | 15 | @ | Wellsville-Middletown | 1 | |
| Louisiana | 9 | vs | Van-Far | 6 | ||
| Mark Twain | 1 | vs | Monroe City | 12 | ||
| Updated 05.03.21 | ||||||